Β-alanine supplementation effect in athletes, physically active and sedentary

  • Caroline Marques Universidade do Estado do Rio de Janeiro
  • Eliane de Abreu Soares Universidade do Estado do Rio de Janeiro
  • Gabriela Morgado de Oliveira Coelho Universidade Federal do Rio de Janeiro. Universidade Estácio de Sá. Faculdade Arthur Sá Earp Neto.
Keywords: Beta-alanine, Exercise, Muscle fatigue, Carnosine, Sports nutrition

Abstract

The aim of this article was to investigate, by systematic review, the effects of β-alanine supplementation on performance of athletes, physically active and sedentary individuals during high intensity exercises. For the bibliographic research the following databases were used: PubMed, Scielo, Science Direct, Scopus and Cochrane. We selected 15 original articles published in eight different countries during, including 118 male athletes from five different sports, and 257 physically active and sedentary individuals, of both sexes, aged between 21 and 29.2 years old, and further 44 elderly individuals aged between 64 to 72.8 years old, from both sexes. This sample received a daily dose of 2 to 6.4g of β-alanine supplementation during 4 to12 weeks. There vised articles showed that β-alanine supplementation demonstrated a beneficial effect for athletes in delaying muscle fatigue and increasing power and muscle strength during high-intensity exercise, while for non-athletes, the main result found was delay fatigue. These results were attributed to the increase of muscle carnosine, due to β-alanine administration. However just thre estudies evaluated this content directly, confirming this hypothesis. No side effects were observed with β-alanine supplementation, considering the administered doses. We can conclude that β-alanine supplementation may be effective in improving performance of athletes, increasing the physical capacity of physically active and sedentary individuals, including elderly people.

Author Biography

Caroline Marques, Universidade do Estado do Rio de Janeiro

Nutricionista (UERJ), Especialista em Ciências da Performance Humana (UFRJ) e graduanda em Educação Fí­sica (Bacharelado-UERJ)

References

-Acree, L.S.; Longfors, J.; Fjeldstad, A.S.; Fjeldstad, C.; Schank, B.; Nickel, K.J.; Montgomery, P.S.; Gardner, A.W. Physical activity is related to quality of life in older adults. Healthand Quality ofLife Outcomes. Vol. 4. Núm. 37. 2006.

-Asatoor, A.M.; Bandoh, J.K.; Lant, A.F.; Milne, M.D.; Navab, F. Intestinal absorption of carnosine and its constituent amino acids in man. Gut. Vol. 11. p. 250-254. 1970.

-Bakardjiev, A.; Bauer, K. Transport of b-alanine and biosynthesis of carnosine by skeletal muscle cells in primary culture. European Journal of Biochemistry. Vol. 225. p. 617-623. 1994.

-Boldyrev, A.A.; Koldobski, A.; Kurella, E.; Maltseva, V.; Stvolinski, S.Natural histidine-containing dipeptide carnosine as a potent hydrophilic antioxidant with membrane stabilizing function: a biomedical aspect. Molecular and Chemical Neuropathology. Vol. 19. p. 185-192. 1993.

-Courneya, K.S.; Mackey, J.R.; Bell, G.J.; Jones, L.W.; Field, C.J.; Fairey, A.S. Randomized controlled trial of exercise training in postmenopausal breast cancer survivors: cardiopulmonary and quality of life outcomes. Journal of Clinical Oncology. Vol. 21. p. 1660-1668. 2003.

-Cruz-Jentoft, A.J.; Baeyens, J.P.; Bauer, J. M.; Boirie, Y.; Cederholm, T.; Landi, F.; Martin, F.C.; Michel, J.P.; Rolland, Y.; Schneider, S.M.; Topinková, E.; Vandewoude, M.; Zamboni, M . Sarcopenia: European consensus on definition and diagnosis, report of the European Working Group on sarcopenia in older people. Age and Ageing. Vol. 39. Núm. 4. p. 412-423. 2010.

-Dennig, H.; Talbott, J.H.; Edwards, H.T.; Dill, D.B. Effect of acidosis and alkalosis upon capacity for work. Journal of Clinical Investigation. Vol. 9. p. 601-613. 1931.

-Derave, W.; Ozdemir, M.S.; Harris, R.C.; Pottier, A.; Reyngoudt, H.; Koppo, K.; Wise, J.A.; Achten, E. β-alanine supplementation augments muscle carnosine content and attenuates fatigue during repeated isokinetic contraction bouts in trained sprinters. Journal of Applied Physiology. Vol. 103. p. 1736-1743. 2007.

-Donovan, T.; Ballam, T.; Morton, J.P.; Close, G.L. β-alanineimproves punch force and frequency in amateur boxers during a simulated contest. International Journal of Sport Nutrition and Exercise Metabolism. Vol. 22. Núm. 5. p. 331-337. 2012.

-Dutka, T.L.; Lamb, G.D. Effect of carnosine on excitation-contraction coupling in mechanically-skinned rat skeletal muscle. Journal of Muscle Research and Cell Motility. Vol. 25. p. 203-213. 2004.

-Edge, J.; Bishop, D.; Goodman, C. The effects of training intensity on muscle buffer capacity in females. European Journal ofApplied Physiology. Vol. 96. Núm. 1. p.97-105. 2006.

-Everaert, I.; Mooyaart, A.; Baguet, A.; Zutinic, A.; Baelde, H.; Achten, E.; Taes, Y.; De Heer, E.; Derave, W. Vegetarianism, female gender and increasing age, but not CNDP1 genotype, are associated with reduced muscle carnosine levels in humans. Amino Acids. Vol. 40. p. 1221-1229. 2011.

-Favero, S.; Roschel, H.; Solis, M.Y.; Hayashi, A.P.; Artioli, G.G.; Otaduy, M.C.; Benatti, F.B.; Harris, R.C.; Wise, J.A.; Leite, C.C.; Pereira, R.M.; Sá-Pinto, A.L.; Lancha Junior, A.H.; Gualano, B. Beta-alanine (CarnosynTM) supplementation in elderly subjects (60–80 years): effects on muscle carnosine content and physical capacity. Amino Acids. Vol. 43. p. 49-56. 2012.

-Geyer, H.; Parr, M.K.; Mareck, U.; Reinhart, U.; Schrader, Y.; Schänzer, W. Analysis of non-hormonal nutritional supplements for anabolic-androgenic steroids-results of an international study. International Journal of Sports Medicine. Vol. 25. p. 124-129. 2004.

-Ghiasvand, R.; Askari, G.; Malekzadeh, J.; Hajishafiee, M.; Daneshvar, P.; Akbari, F.; Bahreynian, M. Effects of six weeks of β-alanine administration on VO2 max, time to exhaustion and lactate concentrations in physical education students. International Journal of Preventive Medicine. Vol. 3. Núm. 8. p. 559-563. 2012.

-Goodpaster, B.H.; Park, S.W.; Harris, T.B.; Kritchevsky, S.B.; Nevitt, M.; Schwartz, A.V.; Simonsick, A.M.; Tylavsky, F.A.; Visser, M.; Newman, A.B. The loss of skeletal muscle strength, mass, and quality in older adults: the health, aging and body composition study. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. Vol. 61. Núm. 10. p. 1059-1064. 2006.

-Harris, R.C.; Marlin, D.J.; Dunnett, M.; Snow, D.H.; Hultman, E. Muscle buffering capacity and dipeptide content in the thoroughbred horse, greyhound dog and man. Comparativa Biochemistry and Physiology. Vol. 97A. p. 249-251. 1900.

-Harris, R.C.; Soderlund, K.; Hultman, E. Elevation of creatine in resting and exercised muscle of normal subjects by creatine supplementation. Clinical Science. Vol. 83. p.367-374. 1992.

-Harris, R.C.; Tallon, M.J.; Dunnett, M.; Boobis, L.; Coakley, J.; Kim, H.J.; Fallowfield, J.L.; Hill, C.A.; Sale, C.; Wise, J.A. The absorption of orally supplied betaalanine and its effect on muscle carnosine synthesis in human vastus lateralis. Amino Acids. Vol. 30. p. 279-289. 2006.

-Helgerud, J.; Hoydal, K.; Wang, E.; Karlsen, T.; Berg, P.; Bjerkaas, M.; Simonsen, T.; Helgesen, C.; Hjorth, N.; Bach, R.; Hoff, J. Aerobic high intensity intervals improve VO2max more than moderate training. Medicine & Science in Sports & Exercise. Vol. 39. Núm. 4. p. 665-671. 2007.

-Hill, C.A.; Harris, R.C.; Kim, H.J.; Harris, B.D.; Sale, C.; Boobis, L.H.; Kim, C.K.; Wise, J.A. Influence of beta-alanine supplementation on skeletal muscle carnosine concentrations and high intensity cycling capacity. Amino Acids. Vol. 32. Núm. 2. p. 225-233. 2007.

-Hoffman, J. The applied physiology of American Football. International. Journal of Sports Physiology and Performance. Vol. 3. p. 387-392. 2008.

-Howe, S.T.; Bellinger, P.M.; Driller, M.W.; Shing, C.M.; Fell, J.W. The effect of β-alanine supplementation on isokinetic force and cycling performance in highly-trained cyclists. International Journal of Sport Nutrition and Exercise Metabolism. Vol. 23. Núm. 6. p. 562-570. 2013.

-Jordan, T.; Lukaszuk, J.; Misic, M.; Umoren, J. Effect of beta-alanine supplementation on the onset of blood lactate accumulation (OBLA) during treadmill running: Pre/post 2 treatment experimental design. Journal of the International Society of Sports Nutrition. Vol. 7. Núm. 20. p. 20-26. 2010.

-Kendric, I.P.; Kim, H.J.; Harris, R.C.; Kim, C.K.; Dang, V.H.; Lam, T.Q.; Bui, T.T.; Wise, J.A. The effect of 4 weeks β-alanine supplementation and isokinetic training on carnosine concentrations in type I and II human skeletal muscle fibres. European Journal of Applied Physiology. Vol. 106. Núm. 1. p. 131-138. 2009.

-Kendric, I.P.; Harris, R.C.; Kim,H.J.; Kim, C.K.; Dang, V.H.; Lam, T.Q.; Bui, T.T.; Smith, M.; Wise, J.A. The effects of 10 weeks of resistance training combined with beta-alanine supplementation on whole body strength, force production, muscular endurance and body composition. Amino Acids. Vol. 34. Núm. 4. p. 547-554. 2008.

-Kern, B.D.; Robinson, T.L. Effects of β-alanine supplementation on performance and body composition in collegiate wrestlers and football players. Journal of Strength and Conditioning Research. Vol. 25. Núm. 7. p. 1804-1815. 2011.

-Kim, H.J.; Kim, C.K.; Harris, R.C.; Harris, D.B.; Sale, C. Effect on muscle fibremorphology and carnosine content after 12 days training of Korean speed skaters. Medicine and Science in Sports & Exercise. Vol. 37. Suppl. 5. S. p.192. 2005.

-Kreider, B.R.; Ferreira, M.; Wilson, M.; Grindstaff, P.; Plisk, S.; Reinardy, J.; Cantler, E.; Almada, A.L. Effects of creatine supplementation on body composition, strength, and sprint performance. Medicine and Science in Sports & Exercise. Vol. 30. p. 73-82. 1998.

-Lamont, C.; Miller, D.J. Calcium sensitizing action of carnosine and other endogenous imidazoles in chemically skinned striated muscle. Journal of Physiology. Vol. 454. p. 421-434. 1992.

-Mannion, A.F.; Jakeman, P.M.; Dunnett, M.; Harris, R.C.; Willan, P.L.Carnosine and anserine concentrations in the quadriceps femoris muscle of healthy humans. European Journal of Applied Physiology. Vol. 64. Núm. 1. p. 47-50. 1992.

-Perry, T.L.; Hansen, S.; Tischler, B.; Bunting, R.; Berry, K. Carnosinemia: a new metabolic disorder associated with neurologic disease and mental defect. New England Journal of Medicine.Vol. 277. p. 1219-1226. 1967.

-Rozenek, R.; Funato, K.;Kubo, J.; Hoshikawa, M.;Matsuo, A.Physiological responses to interval training sessions at velocities associated with VO2max. Journal ofStrengthandConditioningResearch. Vol. 21. Núm. 1. p. 188-192. 2007.

-Sahlin, K.; Edstrom, L.; Hultman, E. Effects of latic acid accumulation and ATP decrease on muscle tension and relaxation. AmericanJournal of Physiology.Vol. 240. p. C121-126. 1981.

-Sale, C.; Hill, C.A.; Ponte, J.; Harris, R.C. β-alanine supplementation improves isometric endurance of the knee extensor muscles. Journalof theInternational SocietyofSports Nutrition.Vol. 9. Núm. 26. p. 26-32. 2012.

-Saunders, B.; Sunderland, C.; Harris, R.C.; Sale, C. β-alanine supplementation improves YoYo intermittent recovery test performance. Journalof the International Society of Sports Nutrition. Vol. 9. Núm. 39. p. 39-43. 2012.

-Silva, R.S.; Silva, I.; Silva, R.A.; Souza, L.; Tomasi, E. Atividade física e qualidade de vida. Ciência e Saúde Coletiva. Vol. 15. Núm. 1. p. 115-120. 2010.

-Smith, A.E.; Walter, A.A.; Graef, J.L.; Kendall, K.L.; Moon, J.R.; Lockwood, C.M.; Fukuda, D.H.; Beck, T.W.; Cramer, J.T.; Stout, J.R. Effects of beta-alanine supplementation and high-intensity interval training on endurance performance and body composition in men; a double-blind trial. Journalof the International Society of Sports Nutrition. Vol. 6. Núm. 5. p. 5-13. 2009.

-Sola-Penna, M. Metabolic regulation by lactate. Life. Vol. 60. Núm. 9. p. 605-608. 2008.

-Stout, J.R.; Cramer, J.T.; Zoeller, R.F.; Torok, D.; Costa, P.; Hoffman, J.R.; Harris, R.C.; O’Kroy, J. Effects of beta-alanine supplementation on the onset of neuromuscular fatigue and ventilatory threshold in women. Amino Acids. Vol. 32. Núm. 3. p. 381-386. 2006b.

-Stout, J.R.; Cramer, J.T.; Mielke, M.; O'Kroy, J.; Torok, D.J.; Zoeller, R.F. Effects of twenty-eight days of beta-alanine and creatine monohydrate supplementation on the physical working capacity at neuromuscular fatigue threshold. Journal of Strength and Conditioning Research. Vol. 20. Núm. 4. p. 928-931. 2006a.

-Stout, J.R.; Graves, B.S.; Smith, A.E.; Hartman, M.J.; Cramer, J.T.; Beck, T.W.; Harris, R.C. The effect of beta-alanine supplementation on neuromuscular fatigue in elderly (55-92 years): a double-blind randomized study. Journal of the International Society of Sports Nutrition. Vol. 5. Núm. 21. p. 21-26. 2008.

-Suzuki, Y.; Ito, O.; Takahashi, H.; Takamatsu, K. The effect of sprint training on skeletal muscle carnosine in humans. International Journal of Sport and Health Science. Vol. 2. p. 105-110. 2004.

-Suzuki, Y.; Ito, O.; Mukai, N.; Takahashi, H.; Takamatsu, K. High level of skeletal muscle carnosine contributes to the latter half of exercise performance during 30-s maximal cycle ergometer sprinting.Japanese Journal of Physiology. Vol. 52. p. 199-205. 2002.

-Tallon, M.J.; Harris, R.C.;Boobis, L.H.; Fallowfield, J.L.; Wise, J.A. The carnosine content of vastus lateralis is elevated in resistance-trained bodybuilders. Journal of Strength and Conditioning Research. Vol. 19. Núm. 4. p. 725-729. 2005.

-Tallon, M.J.; Harris, R.C.;Maffulli, N.;Tarnopolsky, M.A. Carnosine, taurine and enzyme activities of human skeletal muscle fibresfrom elderly subjects with osteoarthritis and young moderately active subjects. Biogerontology. Vol. 8. Núm. 2. p. 129-137. 2007.

-Trivedi, B.; Danforth, W.H. Effect of pH on the kinetics of frog muscle phosphofructokinase. Journal of Biological Chemistry. Vol. 241. Núm. 17. p. 4110-4114. 1966.

-Van Thienen, R.; Van Proeyen, K.; Vanden Eynde, B.; Puype, J.; Lefere, T.; Hespel, P. β-alanine improves sprint performance in endurance cycling. Medicine & Science in Sports & Exercise. Vol. 41. Núm. 4. p. 898-903. 2009.

-Vandebuerie, F.; Vanden Eynde, B.; Vandenberghe, K.; Hespel, P.Effect of creatine loading on endurance capacity and sprint power in cyclists. International Journal of Sports Medicine. Vol. 19. Núm. 7. p. 490-495. 1998.

-Vandenberghe, K.; Goris, M.; Van Hecke, P.; Van Leemputte, M.; Vangerven, L.; Hespel, P.Long-term creatine intake is beneficial to muscle performance during resistance training. JournalofApplied Physiology. Vol. 83. p. 2055-2063. 1997.

-Williams, M.H. Ergogenic aids: a means to citius, altius, fortius, and olympic gold? Research Quarterly for Exercise and Sport. Vol. 67. Núm. 3. p. 58-64. 1996.

-Zoeller, R.F.; Stout, J.R.; O'kroy, J.A.; Torok, D.J.; Mielke, M. Effects of 28 days of beta-alanine and creatine monohydrate supplementation on aerobic power, ventilatory and lactate thresholds, and time to exhaustion. Amino Acids. Vol. 33. Núm. 3. p. 505-510. 2007.

Published
2016-04-28
How to Cite
Marques, C., Soares, E. de A., & Coelho, G. M. de O. (2016). Β-alanine supplementation effect in athletes, physically active and sedentary. Brazilian Journal of Exercise Prescription and Physiology, 9(56), 575-591. Retrieved from https://www.rbpfex.com.br/index.php/rbpfex/article/view/799
Section
Scientific Articles - Original